MTHFR stands for methylenetetrahydrofolate reductase. It is a gene that helps the body produce an enzyme involved in folate metabolism, methylation, and homocysteine processing.

In the clinic, I call it “The Mother Fucker Gene,” but the truth is, we all have it.

What differs is that some people carry common variants, such as C677T or A1298C, which may slightly affect how efficiently the body supports methylation and detoxification.

Having the variant does not automatically mean something is wrong. It simply means the body may need extra support with methylation, energy, detoxification and nervous system regulation.

Generally, if you are reading this, it is because it has been left for too long, your system is overwhelmed and secondary issues are starting to arise. The following information is intended to work alongside having Kinesiology Balances and receiving individual support. The one thing about the difference in gene expression is that outcomes vary, and treatment needs to be individualised. Below is blanket information to use in conjunction with a personalised treatment plan.

It is normally the secondary illnesses or symptoms that lead people to seek support.

The gene itself is never the sole contributor to these issues, but in clinic it often shows up in relation to fertility and reproductive health, including endometriosis and PCOS, hormonal clearance issues, perimenopause, early ageing, early menopause, migraines, chronic inflammation, lymphatic oedema, histamine sensitivity, hay fever and allergies, mast cell activation, sensitive skin, rashes, blood sugar issues, chemical sensitivity and poor recovery after illness.

If you have worked with me for a while, you will know I am not a big fan of long-term supplements or medications. They can be amazing for helping kick the body back into gear, but ideally, the body’s innate ability to harmonise and heal should begin to take over.

This is why I always like to start with food first.

Within the clinic, we focus on two aspects.

The first is building a healthy, functioning detox pathway. The second is to reduce the toxic load already in the system.

Often, patience is needed because there is no point pushing the body to detox if the detox pathways are clogged, sluggish or not flowing well.

This is where it is important to check in with yourself.

How long has the issue been going on?
How toxic does the body feel?
How well supported are your detox pathways?
Are your liver, bowel, lungs, lymphatic system and skin all eliminating well?

The liver can only process what the body can eliminate. If the large intestine and lungs are not clearing properly, the body may try to push waste out through the skin. When the skin is also blocked or overwhelmed, the body can begin storing toxins in tissues, including fat cells, cellulite and scar tissue.

So the easiest and safest next step is to build the methylation pathway and reduce the body’s toxic load.

1. Think processed foods, pesticides, preservatives, artificial colours, numbers and flavour enhancers.

2. Where possible, cook whole foods from scratch. Choose organic when you can, and when you can’t, wash and peel your produce well.

3. Look at toxic cleaning products. Ammonia-based cleaning products and chemical hair dyes can place an extra load on the methylation and detox pathways.

4. Synthetic sprays and perfumes are another big one. Think perfumes in cleaning products, makeup, skincare, shampoo, conditioner, body sprays, hand soaps, air fresheners, deodorisers, deodorants and laundry products.

5. Then there are poor-quality fats. Mineral oils, seed oils, fake oils and oils that have been reheated multiple times can all add extra stress to the body.

The goal is not to panic or throw everything out overnight. The goal is to swap and make better choices as you become aware.

Perfume can be one of the most challenging things to remove as a blanket rule, but once you find good replacement products, it often becomes one of the easiest changes to maintain.

Now, let’s look at supplements.

The world of supplements is much more MTHFR-aware than it was 10 years ago, which is great, but quality still matters.

Vitamin C is your friend, especially liposomal vitamin C. This can support the liver and help the body process and clear stored waste, especially when detox pathways are under pressure.

B vitamins are also important, but they work best as a family. The body often does not respond well to B vitamins when they are separated, isolated or synthetic, which is why I always like to start with food as the best source.

If you do need to supplement, quality matters. Look for a whole, complete methylated B complex. There are a lot more on the market today than there were a few years ago. Thorne Methyl-Guard Plus®, Micro Ingredients Pure Methylated B Complex with Vitamin C, and My Brain Co Active B Complex all look like good options and can be purchased online. I also consistently use My Brain Co creatine and Pure TMG, which I commonly recommend for women over 35.

Zinc and magnesium are also key players. I would usually recommend magnesium through the skin first, either as a magnesium spray or bath salts.

Fibre is your friend too, but keep it clean. Choose fibre without added flavours, colours or synthetic vitamins. Monitoring bowel movements is key. If the bowels are not clearing properly, the body can struggle to eliminate what the liver is trying to process.

Here, I will sometimes recommend celery juice and fibre. Fibre can help clear the bowels, and celery juice may also support fluid retention and gentle detoxification.

But even more important is your water.

Hydration is key to flushing out the fish tank. Filtered water is best. Warm water with lemon in the morning can be a beautiful support, and herbal teas with ginger or nettle can help too.

MTHFR is not a death sentence. It is only the understanding that your body needs a little extra help to detox and clean its system. This is not a bad thing, as when you get it right, you will be healthier.

When you look at all of the above, it is really about choosing cleaner versions of products, foods and everyday items. Not elimination. No restriction. Just slowly reducing the load on the body so it has more space to heal, harmonise, and function as it was designed to.

Go slowly.

You do not need to jump into a million alternative therapies or detoxes. Anything that creates dramatic change too quickly can overload the system. Tools like red light therapy and infrared sauna can be incredibly supportive, but they will only truly benefit the body when the methylation pathway has been re-established, and the detox pathways are open and flowing well.

It is very important not to push through exhaustion or force detoxification before the body is ready. Healing is not about how fast you can clear things out. It is about creating enough safety, nourishment and support for the body to process, release and rebuild sustainably.